Drug Resistance Updates
Volume 1, Issue 6 , Pages 397-406, 1998

Dihydrofolate reductase and antifolate resistance in malaria

  • Worachart Sirawaraporn

      Affiliations

    • Corresponding Author InformationCorrespondence to: Worachart Sirawaraporn, Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand. Tel: 662 246 0063 ext. 6309; Fax: 662 248 0375

Received 25 June 1998; received in revised form 27 August 1998; accepted 31 August 1998.

Abstract 

The dihydrofolate reductase (DHFR, EC 1.5.1.3) domain of Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an attractive target of two important antifolate antimalarials: pyrimethamine (Pyr) and cycloguanil (Cyc). Over recent years, knowledge of malarial DHFR and mechanism(s) of antifolate resistance have increased substantially. These observations have provided an important framework for better understanding the molecular basis of antifolate resistance in malaria. This article provides a brief review and update on molecular aspects relevant to antifolate resistance in malaria.

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PII: S1368-7646(98)80015-0

Drug Resistance Updates
Volume 1, Issue 6 , Pages 397-406, 1998

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