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Drug Resistance Updates
Volume 14, Issue 6
, Pages 251-259
, December 2011
Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance
References
- . Overriding standard decoding: implications of recoding for ribosome function and enrichment of gene expression. Cold Spring Harb. Symp. Quant. Biol. 2001;66:217–232
- . Surveillance for antiviral-agent-resistant herpes simplex virus in the general population with recurrent herpes labialis. Antimicrob. Agents Chemother. 2002;46:3042–3044
- . Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin. Microbiol. Rev. 2003;16:114–128
- . Recoding: translational bifurcations in gene expression. Gene. 2002;286:187–201
- . Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant support reactivation from latently infected mouse trigeminal ganglia. J. Virol. 2007;81:8356–8360
- . Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialie: a UK-based survey. J. Antimicrob. Chemother. 2000;46:324–325
- . A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity. Proc. Natl. Acad. Sci. U.S.A. 2000;97:1536–1541
- . Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses. Virology. 1991;180:793–797
- . Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant. J. Virol. 1998;72:6710–6715
- . Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during co-infection of mouse trigeminal ganglia. J. Gen. Virol. 2006;87:3495–3502
- . Resistant herpes simplex virus type 1 infection: an emerging concern after allogeneic stem cell transplantation. Clin. Infect. Dis. 2000;31:927–935
- . Survey of resistance of herpes simplex virus to acyclovir in northwest England. Antimicrob. Agents Chemother. 1998;42:868–872
- . Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc. Natl. Acad. Sci. U.S.A. 1989;86:4736–4740
- . Antiviral Agents. In: Knipe DM, Howley PM editor. Fields Virology. Philadelphia, PA: Lippincott Williams & Wilkins; 2007;p. 447–485
- . Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. Proc. Natl. Acad. Sci. U.S.A. 1980;77:2265–2269
- . Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir. J. Med. Virol. 1993;1(Suppl):58–66
- . Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J. Comp. Neurol. 1994;339:3–11
- . Viral encephalitis in England, 1989–1998: what did we miss?. Emerg. Infect. Dis. 2003;9:234–240
- . The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 1989;70:869–879
- . Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc. Natl. Acad. Sci. U.S.A. 1977;74:5716–5720
- . Orofacial infection of athymic mice with defined mixtures of acyclovir-susceptible and acyclovir-resistant herpes simplex virus type 1. Antimicrob. Agents Chemother. 1989;33:304–310
- . Herpes simplex virus resistant to acyclovir. A study in a tertiary care center. Ann. Intern. Med. 1990;112:416–422
- . Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy. Antimicrob. Agents Chemother. 1982;21:744–752
- . Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. 2006;20:73–83
- . Genotypic detection of acyclovir-resistant HSV-1: characterization of 67 ACV-sensitive and 14 ACV-resistant viruses. Antiviral Res. 2008;79:28–36
- . Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 1998;178:297–303
- . Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms. Drug Resist. Updat. 2002;5:88–114
- . Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus. J. Gen. Virol. 2003;84:1403–1410
- . Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J. Virol. 2003;77:4703–4709
- . High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J. Virol. 2003;77:2282–2286
- . An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. U.S.A. 2005;102:9667–9672
- . Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J. Virol. 2006;80:6568–6574
- . Sequences that direct significant levels of frameshifting are frequent in coding regions of Escherichia coli. EMBO J. 2003;22:5941–5950
- . Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir. J. Gen. Virol. 2003;84:1393–1401
- . Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?. J. Infect. Dis. 1998;178:618–625
- . Translational recoding induced by G-rich mRNA sequences that form unusual structures. Cell. 1996;86:949–959
- . A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant. Proc. Natl. Acad. Sci. U.S.A. 1994;91:5461–5465
- . High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation. Protein Sci. 2000;9:1685–1699
- . Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient. N. Engl. J. Med. 1993;329:1777–1782
- . Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. J. Virol. 1990;64:5396–5402
- . DNA replication fidelity. Annu. Rev. Biochem. 2000;69:497–529
- . Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus. J. Virol. 1989;63:4976–4978
- . Phosphorylation of acyclovir diphosphate by cellular enzymes. Biochem. Pharmacol. 1982;31:3879–3884
- . Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients. J. Infect. Dis. 2000;182:290–293
- . Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene. J. Med. Virol. 2000;62:247–250
- . Reprogrammed genetic decoding in cellular gene expression. Mol. Cell. 2004;13:157–168
- . Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides. Proc. Natl. Acad. Sci. U.S.A. 2001;98:1471–1476
- . Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates. Antimicrob. Agents Chemother. 1982;22:71–77
- . Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature. 1988;334:320–325
- . Herpes simplex viruses. In: Knipe DM, Howley PM editor. Fields Virology. Philadelphia, PA: Lippincott Williams & Wilkins; 2007;p. 2502–2601
- . Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?. Ann. Intern. Med. 1989;111:893–899
- . Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir. J. Virol. 2001;75:1761–1769
- . Spontaneous reactivation of thymidine kinase-deficient, acyclovir-resistant type-2 herpes simplex virus: masked heterogeneity or reversion?. J. Infect. Dis. 1996;174:476–482
- . Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir. J. Virol. 1997;71:3872–3878
- . Characterization of the DNA polymerase and thymidine kinase genes of herpes simplex virus isolates from AIDS patients in whom acyclovir and foscarnet therapy sequentially failed. J. Infect. Dis. 1999;180:487–490
- . Computational identification of putative programmed translational frameshift sites. Bioinformatics. 2002;18:1046–1053
- . Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization. J. Clin. Virol. 2005;32:7–18
- . [125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase. J. Virol. 1977;24:314–318
- . Chronic vulvar ulceration in an immunocompetent woman due to acyclovir-resistant, thymidine kinase-deficient herpes simplex virus. J. Infect. Dis. 1998;177:543–550
- . Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1. J. Virol. 1989;63:2861–2865
- . Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency. J. Virol. 2000;74:965–974
- . [Identification, by in vitro complementation and purification, of a peptide fraction of Escherichia coli beta-galactosidase]. J. Mol. Biol. 1965;12:918–923
- . Frequency and significance of acyclovir-resistant herpes simplex virus isolated from marrow transplant patients receiving multiple courses of treatment with acyclovir. J. Infect. Dis. 1983;148:1077–1082
- . Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J. Infect. Dis. 2002;185:45–52
- . Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 1995;333:770–775
- . Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. J. Am. Med. Assoc. 2006;296:964–973
- . Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat. Med. 2009;15:886–892
- . Epitopes derived by incidental translational frameshifting give rise to a protective CTL response. J. Immunol. 2006;176:6928–6934
PII: S1368-7646(11)00062-8
doi: 10.1016/j.drup.2011.08.003
© 2011 Elsevier Ltd. All rights reserved.
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Drug Resistance Updates
Volume 14, Issue 6
, Pages 251-259
, December 2011
