« Previous
Next »
Drug Resistance Updates
Volume 9, Issue 1
, Pages 74-86
, February 2006
Microtubule-targeting agents in angiogenesis: Where do we stand?
References
- . Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells. FEBS Lett. 2002;532:256–260
- . Taxanes in paediatric oncology: and now?. Cancer Treat. Rev. 2006;32:65–73
- Rational design of the microtubule-targeting anti-breast cancer drug EM015. Cancer Res. 2006;66:3782–3791
- . Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines. Anticancer Res. 2001;21:2281–2286
- . Kinetics of colchicine binding to purified beta-tubulin isotypes from bovine brain. J. Biol. Chem. 1992;267:13335–13339
- . Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J. Biol. Chem. 2004;279:11686–11695
- . The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin. Cancer Res. 1996;2:1843–1849
- . Vascular remodelling and clinical resistance to antiangiogenic therapy. Drug Resist. Updat. 2004;7:289–300
- . Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer. 2003;3:401–410
- . Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res. 2003;63:4342–4346
- . Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc. Natl. Acad. Sci. (U.S.A.). 2003;100:12917–12922
- . Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 2002;62:6938–6943
- Phase I trial with BMS-275183, a novel oral taxane with promising antitumor activity. Clin. Cancer Res. 2006;12:1760–1767
- . Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 2000;60:1878–1886
- . Anticancer therapeutics: “addictive” targets, mulit-targeted drugs, new drug combinations. Drug Resist. Updat. 2005;8:183–197
- . Resistance to cytotoxic and anti-angiogenic anticancer agents: similarities and differences. Drug Resist. Updat. 2003;6:111–127
- . The role of beta-tubulin isotypes in resistance to antimitotic drugs. Biochim. Biophys. Acta. 2001;1471:O1–O9
- Docetaxel administered on a weekly basis for metastatic breast cancer. J. Clin. Oncol. 2000;18:1212–1219
- Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 2002;62:6831–6836
- . Angiogenesis in cancer and other diseases. Nature. 2000;407:249–257
- Carre, M., Braguer, D., in press. Microtubule damaging agents and apoptosis. In: Fojo, T. (Ed.). Microtubules in Health and Disease. Humana Press.
- Vinorelbine and low-dose cyclophosphamide in the treatment of pediatric sarcomas: pilot study for the upcoming European Rhabdomyosarcoma Protocol. Cancer. 2004;101:1664–1671
- . Dose-escalation study of weekly 1-h paclitaxel administration in patients with refractory cancer. Semin. Oncol. 1997;24:69–71
- Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: antitumor activity and biological effects. Ann. Oncol. 2006;17:232–238
- Damber, J.E., Vallbo, C., Albertsson, P., Lennernas, B., Norrby, K., 2005. The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin. Cancer Chemother. Pharmacol. 1–7 [Epub ahead of print].
- ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature. Cancer Res. 2002;62:7247–7253
- . Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes. Biochemistry. 1997;36:3554–3562
- . A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell. 2003;3:497–509
- . Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Res. 2004;24:1759–1763
- . Anti-vascular tumor therapy: recent advances, pitfalls and clinical perspectives. Drug Resist. Updat. 2004;7:125–138
- . Weekly administration of docetaxel and paclitaxel in metastatic or advanced breast cancer. Oncologist. 2005;10:665–685
- . Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res. 2005;65:9021–9028
- . Centrosomes, microtubules, and microfilaments in the reendothelialization and remodeling of double-sided in vitro wounds. Lab. Invest. 1992;66:722–733
- . Characterization of TNP-470-induced modifications to cell functions in HUVEC and cancer cells. J. Pharmacol. Toxicol. Meth. 2000;43:15–24
- . Phase I and pharmacologic study of paclitaxel administered weekly in patients with relapsed ovarian cancer. J. Clin. Oncol. 1997;15:187–192
- . Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971;285:1182–1186
- . Cancer without disease. Nature. 2004;427:787
- . Phase III comparison of high-dose paclitaxel
+
cisplatin
+
granulocyte colony-stimulating factor versus low-dose paclitaxel
+
cisplatin in advanced head and neck cancer: Eastern Cooperative Oncology Group Study E1393. J. Clin. Oncol. 2001;19:1088–1095 - . Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res. 2001;21:93–102
- The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Clin. Cancer Res. 2003;9:3476–3485
- . Antiangiogenic scheduling of lower dose cancer chemotherapy. Cancer J. 2001;7:427–436
- . Regulation of microtubule stability and mitotic progression by survivin. Cancer Res. 2002;62:2462–2467
- . Thoracic radiation therapy and concomitant low-dose daily paclitaxel in non-small cell lung cancer: a phase I study. Oncol. Rep. 2005;14:1647–1653
- . Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc. Natl. Acad. Sci. (U.S.A.). 2001;98:11737–11742
- . Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere). Int. J. Cancer. 2003;104:121–129
- . Docetaxel (Taxotere) administered in weekly schedules. Semin. Oncol. 1999;26:28–31
- Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks. J. Clin. Oncol. 2005;23:5983–5992
- . Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis. Angiogenesis. 1999;3:147–158
- . Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 2004;64:1570–1574
- . Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J. Clin. Invest. 2000;105:1045–1047
- . In vitro pharmacological characterizations of the anti-angiogenic and anti-tumor cell migration properties mediated by microtubule-affecting drugs, with special emphasis on the organization of the actin cytoskeleton. Int. J. Oncol. 2002;21:417–425
- . Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res. 2004;64:8249–8255
- . Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. Br. J. Cancer. 2001;84:290–295
- . Understanding microtubule dynamics for improved cancer therapy. Cell. Mol. Life Sci. 2005;62:3039–3056
- . Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center. Mol. Cancer Ther. 2002;1:1191–1200
- . Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Res. 2003;23:1433–1440
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004;350:2335–2342
- . Drug resistance and P-glycoprotein expression in endothelial cells of newly formed capillaries induced by tumors. Anticancer Res. 1998;18:2977–2980
- . mRNA localization: message on the move. Nat. Rev. Mol. Cell. Biol. 2001;2:247–256
- . Concurrent hyperfractionated radiotherapy and low-dose daily carboplatin/paclitaxel in patients with early-stage (I/II) non-small-cell lung cancer: long-term results of a phase II study. J. Clin. Oncol. 2005;23:6873–6880
- . Concurrent hyperfractionated radiotherapy and low-dose daily carboplatin and paclitaxel in patients with stage III non-small-cell lung cancer: long-term results of a phase II study. J. Clin. Oncol. 2005;23:1144–1151
- . Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr. Med. Chem. Anticancer Agents. 2002;2:1–17
- . Microtubules as a target for anticancer drugs. Nat. Rev. Cancer. 2004;4:253–265
- . Phase II study of weekly low-dose paclitaxel for relapsed and refractory non-Hodgkin's lymphoma: a Wisconsin Oncology Network Study. Cancer Invest. 2005;23:13–18
- . Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog. Cancer Chemother. Pharmacol. 2005;56:145–153
- . BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability. J. Biol. Chem. 2005;280:12902–12907
- . Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer. 2002;2:727–739
- . Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays. 1991;13:31–36
- . Tumor angiogenesis: past, present and the near future. Carcinogenesis. 2000;21:505–515
- . The anti-angiogenic basis of metronomic chemotherapy. Nat. Rev. Cancer. 2004;4:423–436
- . Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 1997;57:81–86
- . Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 2000;105:R15–R24
- . Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin. Cancer Res. 2002;8:221–232
- Kruckzynski, A., Astruc, J., Chazottes, E., Berrichon, G., Ricome, C., Dejean, C., Duflos, A., Fahy, J., Hill, B.T., 2003. Vinflunine, the latest Vinca alkaloid in clinical development, exhibits superior antiangiogenic activity relative to vinorelbine and its derivatives. In: Proceedings of the AACR-NCI-EORTC 15, #B22 (Abstract).
- . Paclitaxel encapsulated in cationic liposomes diminishes tumor angiogenesis and melanoma growth in a “humanized” SCID mouse model. J. Invest. Dermatol. 2003;120:476–482
- . Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn. J. Cancer Res. 2002;93:417–425
- . Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer. Cancer Biother. Radiopharm. 1999;14:31–36
- . Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J. Cell. Mol. Med. 2002;6:1–12
- . Control of apoptosis and mitotic spindle checkpoint by survivin. Nature. 1998;396:580–584
- . Energetics of vinca alkaloid interactions with tubulin isotypes: implications for drug efficacy and toxicity. Cell Motil. Cytoskelet. 1998;39:107–121
- Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 2001;7:1194–1201
- . 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363–375
- . Oral delivery of taxanes. Invest. New Drugs. 2001;19:155–162
- Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res. 2002;62:2731–2735
- . Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood. 2001;97:3658–3661
- Mancuso, P., Colleoni, M., Calleri, A., Orlando, L., Maisonneuve, P., Pruneri, G., Agliano, A., Goldhirsch, A., Shaked, Y., Kerbel, R.S., Bertolini, F., in press. Circulating endothelial cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy. Blood.
- . Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2. Blood. 2003;102:4399–4406
- . Low dose-intensity docetaxel in the treatment of pre-treated elderly patients with metastatic breast cancer. J. Exp. Clin. Cancer Res. 2005;24:43–48
- . Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition. Int. J. Cancer. 2005;113:490–498
- . Vascular-targeting activity of ZD6126, a novel tubulin-binding agent. Cancer Res. 2003;63:1534–1537
- . Redefining the target: chemotherapeutics as antiangiogenics. J. Clin. Oncol. 2001;19:1195–1206
- Miller, K.D., Sweeney, C.J., Sledge, G. W., Jr., 2005a. Can tumor angiogenesis be inhibited without resistance? In: Clauss, C., Breier, G. (Eds.). Mechanisms of Angiogenesis. Exs, Birkhauser, pp. 95–112.
- Miller, K.D., Wang, M. Gralow, J., Dickler, M., Cobleigh, M.A., Perez, E.A., Shenkier, T.N., Davidson, N.E., 2005b. A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 41 (Symposium).
- . Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res. 2001;61:4341–4344
- . Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist. Updat. 2003;6:355–361
- Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies. J. Clin. Oncol. 2003;21:3955–3964
- . Anti-angiogenic treatment of breast cancer using metronomic low-dose chemotherapy. Breast. 2005;14:466–479
- . Multicenter, randomized comparative study of two doses of paclitaxel in patients with metastatic breast cancer. J. Clin. Oncol. 1996;14:1858–1867
- . The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin. Cancer Res. 2006;12:1839–1849
- . Taxane-mediated antiangiogenesis in vitro: influence of formulation vehicles and binding proteins. Cancer Res. 2004;64:821–824
- . Metronomic ABI-007 therapy: antiangiogenic and antitumor activity of a nanoparticle albumin-bound paclitaxel. Proc. Am. Assoc. Cancer Res. 2005;46:2988;(Abstract)
- . Up-regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res. 2001;61:2183–2188
- . Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. Mol. Cancer Ther. 2004;3:1301–1310
- . Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res. 2005;65:2433–2440
- . Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J. Med. Chem. 2006;49:1271–1281
- . Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells. Cancer Res. 2006;66:3256–3263
- . IDN 5390: an oral taxane candidate for protracted treatment schedules. Br. J. Cancer. 2003;88:965–972
- . Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?. Nat. Rev. Cancer. 2002;2:826–835
- . Daily paclitaxel and thoracic radiation therapy for non-small cell lung cancer: preliminary results. Semin. Radiat. Oncol. 1999;9:130–135
- . The involvement of endothelial progenitor cells in tumor angiogenesis. J. Cell. Mol. Med. 2004;8:294–300
- . Vinblastine inhibits the angiogenic response induced by adrenomedullin in vitro and in vivo. Oncogene. 2003;22:6458–6461
- . Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc. Natl. Acad. Sci. (U.S.A.). 2001;98:12485–12490
- . Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy. Clin. Cancer Res. 2003;9:2335–2341
- . Will weekly work? Seems to be so. J. Clin. Oncol. 2005;23:5873–5874
- . Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel. Mol. Cancer Ther. 2005;4:2001–2007
- . Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity. Blood. 2005;106:3058–3061
- . Alterations of beta-tubulin isotypes in breast cancer cells resistant to docetaxel. FASEB J. 2005;19:1299–1301
- . Colchicine and 2-methoxyestradiol inhibit human angiogenesis. J. Surg. Res. 2005;125:104–108
- . Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N. Engl. J. Med. 2004;351:250–259
- . Neovascular targeting chemotherapy: encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature. Int. J. Cancer. 2004;110:117–124
- . The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res. 2001;61:3369–3372
- . Potential antagonism of tubulin-binding anticancer agents in combination therapies. Clin. Cancer Res. 2005;11:2720–2726
- . IDN 5390: a new concept in taxane development. Anticancer Drugs. 2003;14:255–258
- . Vascular targeting agents as cancer therapeutics. Clin. Cancer Res. 2004;10:415–427
- . Disrupting tumour blood vessels. Nat. Rev. Cancer. 2005;5:423–435
- . Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res. 2001;61:6413–6422
- . A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc. Natl. Acad. Sci. (U.S.A.). 2002;99:4349–4354
- . Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood. 1999;94:4143–4155
- . Docetaxel versus paclitaxel for antiangiogenesis. J. Hematother. Stem Cell Res. 2002;11:103–118
- . The expression of thrombospondin-1 in benign prostatic hyperplasia and prostatic intraepithelial neoplasia is decreased in prostate cancer. BJU Int. 2004;93:1339–1343
- . Direct effect of Taxol on free radical formation and mitochondrial permeability transition. Free Radic. Biol. Med. 2001;31:548–558
- . Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney. Cell Motil. Cytoskelet. 1999;42:274–284
- . Mechanism of localization of betaII-tubulin in the nuclei of cultured rat kidney mesangial cells. Cell Motil. Cytoskelet. 2001;49:208–217
- . Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly. Anticancer Drugs. 2003;14:13–19
- Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 2004;10:145–147
- Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs. Ann. Surg. 2003;237:790–800
- . Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy. Clin. Cancer Res. 2005;11:6678–6685
- . The betaII isotype of tubulin is present in the cell nuclei of a variety of cancers. Cell Motil. Cytoskelet. 2004;57:96–106
PII: S1368-7646(06)00023-9
doi: 10.1016/j.drup.2006.04.003
© 2006 Elsevier Ltd. All rights reserved.
« Previous
Next »
Drug Resistance Updates
Volume 9, Issue 1
, Pages 74-86
, February 2006
