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Drug Resistance Updates
Volume 9, Issue 1
, Pages 1-18
, February 2006
Tyrosine kinase inhibitors and gemcitabine: New treatment options in pancreatic cancer?
References
- . Phase I studies with the novel nucleoside analog gemcitabine. Semin. Oncol. 1996;23:25–31
- . Epidemiology and risk factors in pancreatic cancer. Semin. Oncol. 1996;23:241–250
- . Chemotherapy for pancreatic carcinoma. Cancer. 1996;654–663
- . Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin. Cancer Res. 2004;10:6388S–6392S
- Gemcitabine and oxaliplatin for metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group Phase II study. Ann. Oncol. 2003;14:580–585
- Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells. J. Gastrointest. Surg. 2004;8:960–969
- . The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J. Clin. Oncol. 2001;19:32–40
- . Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin. Oncol. 2002;29:3–9
- . Biochemical and clinical aspects of efflux pump related resistance to anti-cancer drugs. Anticancer Res. 1998;18:2937–2944
- Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumors. Br. J. Cancer. 2005;92:1855–1861
- Baerman, K.M., Caskey, L.S., Dasi, F., et al., 2005. EGFR/HER2 targeted therapy inhibits growth of pancreatic cancer cells. ASCO, Gastrointestinal Cancers Symposium (A84).
- . Angiogenesis and cancer metastasis: antiangiogenic therapy of human pancreatic adenocarcinoma. Int. J. Clin. Oncol. 2001;6:59–65
- . Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res. 2002;62:1996–2003
- Magnetic resonance imaging in an orthotopic rat model: blockade of epidermal growth factor receptor with EMD72000 inhibits human pancreatic carcinoma growth. Int. J. Cancer. 2005;114:131–138
- . Vacular remodelling and clinical resistance to antiangiogenic cancer therapy. Drug Resist. Update. 2004;7:289–300
- Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 2003;111:1287–1295
- Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J. Clin. Oncol. 2002;20:3270–3275
- . Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics. Drug Resist. Update. 2005;8:75–83
- Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine. Eur. J. Pharmacol. 2004;498:9–18
- Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br. J. Surg. 1995;82:111–115
- . The diagnosis of pancreatic cancer. Cancer J. 2001;7:287–297
- . Pancreatic cancer. Curr. Opin. Oncol. 1998;10:362–366
- Phase II study of gemcitabine in combination with cisplatin in patients with locally advanced and/or metastatic pancreatic cancer. Anticancer Drugs. 2000;11:623–628
- . Anticancer therapeutics: “Addictive targets”, multi-targeted drugs, new drug combinations. Drug Resist. Update. 2005;8:183–197
- Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin. Cancer Res. 2000;6:1936–1948
- Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 2000;60:2926–2935
- Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice. Int. J. Cancer. 2002;102:101–108
- Anti-angiogenic and anti-tumor activity of a novel VEGFR-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. Proc. Am. Assoc. Cancer Res. 2003;44:604;(A3041)
- Therapy for pancreatic cancer with a recombinant humanized anti-HER2 antibody (herceptin). J. Gastrointest. Surg. 2001;5:139–146
- VEGF-RII influences the prognosis of pancreatic cancer. Ann. Surg. 2002;236:738–749
- Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy. Int. J. Oncol. 2005;27:1125–1130
- Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation. Int. J. Radiat. Oncol. Biol. Phys. 2002;54:1180–1193
- Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 1997;15:2403–2413
- . Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist. 2004;9(Suppl. 3):10–15
- Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 2005;23:5305–5313
- Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br. J. Cancer. 1996;73:101–105
- Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs. 1994;12:29–34
- Clinically meaningful improvement in symptoms and quality of life for patients with non-small-cell lung cancer receiving gefitinib in a randomized controlled trial. J. Clin. Oncol. 2005;23:2946–2954
- Chen, J., Rocken, C., Nitsche, B., et al., 2005. The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression. Cancer Lett. xx, pp. 1–10 (Epub ahead of print).
- The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005;65:18–25
- Randomized trial of gemcitabine (GEM) alone or with cisplatin (CDDP) in the treatment of advanced pancreatic cancer: a Phase II multicenter study of the Southern Italy Oncology Group. Proc. Am. Soc. Clin. Oncol. 1999;18:250;(A961)
- . Resistance to tyrosine kinase inhibitors: calling on extra forces. Drug Resist. Update. 2005;8:119–129
- . A decade of tyrosine kinases: from gene discovery to therapeutics. Surg. Oncol. 2003;12:39–49
- A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. Fluorouracil versus fluorouracil and doxorubicin versus fluorouracil, doxorubicin, and mitomycin. JAMA. 1985;253:2061–2067
- Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. Clin. Cancer Res. 2005;11:678–689
- . New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers. Oncologist. 2004;9:282–294
- Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res. 1998;18:4613–4619
- Phase I clinical evaluation of AZD2171, a highly potent VEGF-receptor tyrosine kinase inhibitor, in patients with advanced tumors. J. Clin. Oncol. 2005;23(Suppl.):192;(A3002)
- A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma. Ann. Oncol. 2002;13:1185–1191
- Defining the role of the epidermal growth factor receptor in pancreatic cancer grown in vitro. Am. J. Surg. 2003;186:431–436
- Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 2004;10:2307–2318
- siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. J. Am. Coll. Surg. 2004;198:953–959
- . Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 2002;20:4368–4380
- Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. Int. J. Cancer. 1995;62:529–535
- . Angiogenesis inhibitors in clinical development; where are we now and where are we going?. Br. J. Cancer. 2004;90:1–7
- The efficacy of tyrosine kinase inhibitors on human pancreatic cancer cell lines. J. Surg. Res. 2003;115:219–225
- Src stimulates insulin-like growth factor I (IGF-I)-dependent cell proliferation by increasing IGF-I receptor number in human pancreatic carcinoma cells. Cancer Res. 1998;58:3551–3554
- SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999;59:99–106
- Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody. Int. J. Radiat. Oncol. Biol. Phys. 2004;58:984–990
- A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994;265:1093–1095
- . Therapeutically targeted anticancer agents: inhibitors of receptor tyrosine kinases. Mini. Rev. Med. Chem. 2004;4:273–283
- . Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin. Oncol. 2001;28:27–33
- A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5- ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055. J. Med. Chem. 2003;46:5375–5388
- Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line. Cancer Res. 1999;59:4204–4207
- SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res. 2003;63:375–381
- SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res. 2005;65:5358–5364
- Phase I study of humanized IgG1 anti-epidermal growth factor receptor (EGFR) monoclonal antibody EMD 72000 plus gemcitabine (Gem) in advanced pancreatic cancer. J. Clin. Oncol. 2004;22(Suppl. 14):(A3061)
- . Kinase inhibitors and cytotoxic drug resistance. Clin. Cancer Res. 2004;10:2205–2207
- Preclinical activity of AZD0530, a novel oral potent and selective inhibitor of Src family kinases. Eur. J. Cancer. 2004;2;(A361)
- Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res. 2002;62:1702–1706
- Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann. Oncol. 2000;11:1399–1403
- . Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 1999;79:1283–1316
- Genetics of pancreatic cancer. From genes to families. Surg. Oncol. Clin. N. Am. 1998;7:1–23
- Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody. J. Surg. Res. 2003;111:274–283
- Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin. Cancer Res. 2003;9:6534–6544
- Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a Phase I study. Am. J. Clin. Oncol. 2005;28:570–575
- Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am. J. Pathol. 2004;165:35–52
- Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness. Surgery. 2003;134:221–226
- . Gemcitabine-based therapy in pancreas cancer: gemcitabine-docetaxel and other novel combinations. Cancer. 2002;95:923–927
- Cancer statistics, 2002. CA Cancer J. Clin. 2002;52:23–47
- Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. U.S.A. 1995;92:3566–3570
- . Pancreatic cancer, Adjuvant combined radiation and chemotherapy following curative resection. Arch. Surg. 1985;120:899–903
- . The pemetrexed/gemcitabine combination in pancreatic cancer. Cancer. 2002;95:928–932
- Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann. Surg. 1999;230:776–782
- A multi-institutional Phase II study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer. Clin. Cancer Res. 2001;7:800–805
- Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res. 1994;54:6106–6114
- . Combination chemotherapy for advanced pancreatic cancer—has its time finally come?. Lancet Oncol. 2005;6:352–353
- Kuo, T., Fitzgerald, A., Kaiser, H., et al., 2006. A Phase I study of the VEGF-receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK 222584) and gemcitabine in patients with advanced pancreatic cancer. ASCO, Gastrointestinal Cancers Symposium, (A127).
- SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice. FASEB J. 2002;16:681–690
- The epidermal growth factor receptor in human pancreatic cancer. J. Pathol. 1992;166:7–12
- . Tyrosine kinase inhibition: an approach to drug development. Science. 1995;267:1782–1788
- . Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol. Ther. 1999;82:231–239
- Pancreatic cancer. Lancet. 2004;363:1049–1057
- Effects of STI571 (gleevec) on pancreatic cancer cell growth. Mol. Cancer. 2003;2:32
- Gefitinib (’Iressa’, ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. Int. J. Oncol. 2004;25:203–210
- Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD Phase III trial. J. Clin. Oncol. 2005;23:3509–3516
- . Gemcitabine in cisplatin-resistant ovarian cancer. Semin. Oncol. 1996;23:72–76
- Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem. Biophys. Res. Commun. 1998;243:503–508
- Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer Res. 2001;61:3508–3517
- Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997;276:955–960
- . Brief communication: a new combination in the treatment of advanced pancreatic cancer. Semin. Oncol. 2005;32:5–6
- Moore, M.J., Goldstein, D., Hamm, J., et al., 2005. Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer. A Phase III trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG). ASCO, Gastrointestinal Cancers Symposium, (A77).
- Preliminary report of a Phase 1 study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), given in combination with gemcitabine to patients with advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 2003;22:197;(A778)
- . Bevacizumab in combination chemotherapy for colorectal and other cancers. Am. J. Health Syst. Pharm. 2005;62:1021–1032
- A randomised, prospective, multicenter, Phase III trial of adjuvant chemotherapy with gemcitabine versus observation in patients with resected pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 2005;23:311;(A4013)
- Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol. Cancer Ther. 2002;1:777–783
- Prognostic significance of c-erbB-2 gene expression in pancreatic cancer patients. Neoplasma. 2001;48:188–191
- An innovative Phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin. Cancer Res. 2003;9:5465–5476
- A randomized Phase III trial of DX-8951f (exatecan mesylate; DX) and gemcitabine vs gemcitabine alone in advanced pancreatic cancer. J. Clin. Oncol. 2004;22(Suppl. 14):314;(A4006)
- . Gemcitabine in combination with 5-fluorouracil with or without folinic acid in the treatment of pancreatic cancer. Cancer. 2002;95:912–922
- . Epidermal-growth-factor-dependent activation of the src-family kinases. Eur. J. Biochem. 1994;225:1047–1053
- Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer. 2000;89:74–82
- Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer. 2001;92:569–577
- . Gemcitabine and platinum combinations in pancreatic cancer. Cancer. 2002;95:908–911
- Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 2001;61:2929–2934
- . A multitargeted, metronomic, and maximum-tolerated dose “chemo-switch” regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 2005;23:939–952
- A Phase I study of the pan-VEGFR tyrosine kinase inhibitor, CEP-7055, in patients with advanced malignancy. Proc. Am. Soc. Clin. Oncol. 2003;22:207;(A831)
- A Phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin. Cancer Res. 2003;9:1323–1332
- Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 1999;59:5209–5218
- Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre Phase III trial. Lancet Oncol. 2005;6:369–376
- A randomized Phase III study comparing gemcitabine
+
pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreatic cancer. J. Clin. Oncol. 2004;22(Suppl. 14):(A4007) - Results of a Phase I trial of BAY 43-9006 in combination with doxorubicin in patients with primary hepatic cancer. Int. J. Clin. Pharmacol. Ther. 2004;42:650–651
- Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer. J. Clin. Oncol. 2002;20:1182–1191
- Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J. Clin. Oncol. 2004;22:3776–3783
- . Pancreatic carcinoma. Lancet. 1997;349:485–489
- A Phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann. Oncol. 1996;7:347–353
- CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. Cancer Res. 2003;63:5978–5991
- Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J. Clin. Oncol. 2005;23:5474–5483
- . ZD6474—a novel inhibitor of VEGFR and EGFR tyrosine kinase activity. Br. J. Cancer. 2005;92(Suppl. 1):6–13
- . Molecular-targeted agents in pancreatic cancer. Cancer Control. 2004;11:32–38
- Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am. J. Clin. Oncol. 2001;24:496–499
- Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu. Cancer Invest. 2004;22:706–712
- Safran, H., Iannitti, D., Miner, T., et al., 2006. GW572016/gemcitabine and GW572016/gemcitabine/oxaliplatin, a two-stage, Phase I study for advanced pancreaticobiliary cancer. ASCO, Gastrointestinal Cancers Symposium, (A124).
- Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival. Am. J. Surg. Pathol. 2005;29:1125–1134
- Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225. J. Gastrointest. Surg. 2003;7:37–43
- Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma. Clin. Cancer Res. 2001;7:2563–2572
- Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother. Radiopharm. 2001;16:359–370
- Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J. Clin. Oncol. 2005;23:2502–2512
- Treatment of pancreatic cancer with a combination of docetaxel, gemcitabine and granulocyte colony-stimulating factor: a Phase II study of the Greek Cooperative Group for Pancreatic Cancer. Ann. Oncol. 2001;12:101–103
- Treatment of pancreatic cancer with a combination of irinotecan (CPT-11) and gemcitabine: a multicenter Phase II study by the Greek Cooperative Group for Pancreatic Cancer. Ann. Oncol. 2003;14:388–394
- . Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev. 2003;22:337–358
- AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol. Cancer Ther. 2005;4:1900–1911
- A Phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc. Am. Soc. Clin. Oncol. 2003;22:192;(A770)
- Anticancer effects of ZD6474, a VEGF-receptor tyrosine kinase inhibitor, in gefitinib (“Iressa”)-sensitive and resistant xenograft models. Cancer Sci. 2004;95:984–989
- Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366:1527–1537
- Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res. 2005;65:7214–7222
- Trevino, J.G., Summy, J.M., Sawyer, T.K., et al., 2005b. Angiogenesis is regulated by Src family kinases in pancreatic adenocarcinoma. ASCO, Gastrointestinal Cancers Symposium, (A152).
- Systemic treatment of pancreatic cancer. Eur. J. Gastroenterol. Hepatol. 2004;16:265–274
- ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. 2000;60:970–975
- AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 2005;65:4389–4400
- BAY 43-9006 exhibits broad-spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099–7109
- Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents. Bioorg. Med. Chem. Lett. 2002;12:2893–2897
- Meta-analysis of inoperable pancreatic cancer: gemcitabine combined with cisplatin versus gemcitabine alone. Chin. J. Dig. Dis. 2006;7:49–54
- . Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Semin. Oncol. 2002;29:31–37
- Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter Phase II Trial. J. Clin. Oncol. 2004;22:2610–2616
- Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of platelet-derived growth factor-B. Biochem. Biophys. Res. Commun. 1996;222:700–705
- Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res. 1993;13:565–569
- Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 1999;59:1236–1243
- Development of ABX-EGF, a fully human anti-EGF-receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001;38:17–23
- Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin. Cancer Res. 2004;10:8028–8036
- Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity. Leukemia. 2003;17:60
PII: S1368-7646(06)00004-5
doi: 10.1016/j.drup.2006.02.002
© 2006 Elsevier Ltd. All rights reserved.
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Drug Resistance Updates
Volume 9, Issue 1
, Pages 1-18
, February 2006
